IMMUNOLOGY MCQ EXAM
1. All of the following are true with respect to IgM
antibodies EXCEPT which one
A. they fix complement
B. they occur on the surface of
lymphocytes
C. they predominate in the
primary response to antigen
D. they are glycoproteins
E. they mediate allergic
reaction
2. One principal function of complement is to
A. inactivate perforins
B. mediate the release of
histamine
C. Bind antibodies attached to
cell surfaces and to lyse these cells
D. phagocytize antigens
E. cross link allergens
3. One principal function of the Class I and Class II
major histocompatibility complex S proteins is to
A. transduce the signal to the
T-cell interior following antigen binding
B. mediate immunoglobulin class
switching
C. present antigen for
recognition by the T-cell antigen receptor
D. stimulate production of
interleukins
E. bind complement
4. The major role of the complement system is to work
in conjunction with
A. antibodies to lyse cells via
the C8 and C9 components
B. the major histocompatibility
complex for cell recognition
C. antibodies to opsonize
cells
D. the T-cell receptor for
production of lymphokines
E. antibodies to lyse cells via
the perforin molecules
5. T-cell antigen receptors are distinguished from
antibodies by which of the following
A. T-Cell receptors are
glycosylated
B. T-cell receptors must
interact with antigen uniquely presented by other cells but not with free
antigen
C. T-Cell receptors bind
various cytokines
D. T-Cell receptors bind
complement to lyse cells
E. T-cell receptors are
mediators of allergic reactions
6. T-cell receptors or antibodies react with antigens
A. because both are made by
lymphocytes
B. because of complementary of
molecular fit of both with antigen
C. because both 'have light
chain and heavy chain polypeptides
D. cause histamine release
E. facilitate perforin
release
7. All of the following are true of antigen EXCEPT
which one of the following?
A. They contain epitopes.
B. They will react with
antibodies.
C. They contain antigenic
determinants.
D. They can elicit an immune
response.
E. They contain paratopes.
8. All of the following are true with respect to IgE
molecules, EXCEPT which one?
A. They are the principal
immunoglobulin class involved in allergic reactions.
B. They are involved in
mediating anti-parasitic immune responses.
C. They will cross the placenta
and fix complement.
D. They can effect the release
of histamine and other chemical mediators.
E. They are the least abundant
immunoglobulin in the serum.
9. Which of the following immunoglobulins is present
normally in plasma at the highest concentration?
A. IgG
B. IgM
C. IgA
D. IgD
E. IgE
10. All of the following are true about antibodies,
EXCEPT which one?
A. They fix complement.
B. They occur on the surface of
B-lymphocyte
C. They predominate the primary
immune response to antigen.
D. They are glycoproteins.
E. They are molecule with a
single, defined amino acid sequence.
11. The major immunoglobulin family to which a
particular immunoglobulin belongs can be determined by sequential analysis of
the 110 amino acids beginning from the
A. Amino terminus of the light
chain.
B. Carboxy terminus of the
light chain.
C. Amino terminus of the heavy
chain.
D. Carboxy terminus of the
heavy chain.
E. None of the above
12. The immunoglobulin Joining chain (J-chain) is
A. only produced by
T-Cells
B. only produced by
neutrophils
C. associated with only
multimeric forms of lgM and IgA
D. associated with IgE for
histamine release
E. only produced by mast
cells
13. All of the following are true EXCEPT
A. An epitope is a small
portion of a macromolecule
B. the variable region domains
contain the antigen recognition site
C. an antigenic determinant is
a paratope
D. The class of an
immunoglobulin is determined by its heavy chain
E. An IgG antibody is
bivalent
14. Which immunoglobulin is the principal one found in
secretions such as milk?
A. IgG
B. IgM
C. IgA
D. IgD
E. IgE
15. Individuals unable to make the J protein found in
certain immunoglobulins would be expected to have frequent infections of the
A. brain.
B. blood.
C. liver.
D. pancreas.
E. intestinal tract.
16. Which of the following statements best
characterizes an antibody?
A. An antibody contains high
molecular weight RNA as its basic structure.
B. An antibody is composed of
protein and cannot be distinguished from the albumin fraction of the serum
proteins.
C. An antibody is composed of
four identical protein subunits which may be caused to dissociate by treatment
with urea.
D. An antibody contains protein
as its major chemical component and its synthesis may be elicited by the
administration of a foreign protein or polysaccharide.
E. An antibody contains
mucopolysaccharides as its major chemical component and the synthesis of these
may be elicited by the administration of a foreign protein or
polysaccharide.
17. The immunoglobulin class which is the least
abundant in the normal adult is
A. IgG
B. IgA
C. IgM
D. IgD
E. IgE.
18. Class switching of immunoglobulins occurs
A. Usually with booster
immunizations, going from IgM to IgG
B. binds complement
C. causes the histamine
release
D. mediates immunoglobulin
class switching
E. results in the glycosylation
of immunoglobulins
19. When a B-cell undergoes immunoglobulin class
switching
A. the variable region of the
light chain changes, but its constant region remains the same
B. the variable region of the
light chain remains the same, but its constant region changes
C. the variable region of the
heavy chain remains the same but its constant region changes
D. the variable region of the
heavy chain changes but its constant region remains the same
E. both the variable and constant
regions change
20. The class of an immunoglobulin
A. is determined by Class I and
Class II major histocompatibility complex proteins
B. is determined by the
carbohydrate attached to the light chain is
C. determined by the
antigen
D. is determined by the heavy
chain type
E. Is determined by the
J-chain
21. The class of an immunoglobulin is determined by
A. the variable region
B. the J-chain
C. the heavy chain
D. the carbohydrate
E. the T3 polypeptide
complex
22. Light chains are
A. specific for each class of
antibody
B. not specific for each class
of antibody
C. reactive with antigen
D. have only a constant
region
E. are composed only of
carbohydrate
23. Each of the following is a characteristic of
antibodies, EXCEPT which one?
A. they are proteins with
variable and constant regions
B. they contain
carbohydrates
C. they are only secreted by
T-cells
D. they can combine very
specifically with antigen
E. they are structurally
organized in globular domains
24. The T3 complex of the T-cell receptor
A. probably functions to
transduce a signal to the cell's interior following binding of complexed
antigen
B. binds complement
C. causes the histamine
D. mediates Immunoglobulin
class switching
E. results in the glycosylation
of immunoglobulins
25. Cytokines are produced by cells of the immune
system in response to various physiological stimuli
A. modulate cell function
through subsequent cell differentiation or cell proliferation
B. facilitate cell lysis
C. cause glycosylation of
Immunoglobins
D. cause histamine release
E. facilitate perforin
release
26. Which of the following uniquely distinguishes the
T-cell receptor (TCR) from an antibody?
A. The TCR can bind an antigen
fragment only in a trimolecular complex with either the class I or class II
surface proteins of the major histocompatibility complex
B. The TCR can function as a
cell surface antigen receptor
C. The TCR is composed of two
different types of polypeptide chains
D. The TCR is capable of
participating in a cytotoxic reaction.
E. The TCR polypeptides are
composed of domains - an amino terminal variable portion at determines the
binding specificity and a constant portion that determines the class of the
polypeptide chain.
27. Which of the following is NOT true of
interleukins?
A. They are cytokines which can
be produced by various cells of the immune system.
B. They are hormones which
allow one cell to communicate with another cell.
C. They are in need of
receptors on the target cell in order to mediate their effects.
D. They are able bind antigen
with a high level of specificity.
E. They are able to modulate
various aspects of the B-cell arm of immune system.
28. Which of the following is NOT true of T4 and T8
cell markers?
A. These are both surface
glycoproteins expressed on T-cells.
B. These serve to distinguish
different types of T-cells, e.g., helper, suppressor and cytotoxic, from each
other.
C. These are not found
associated with immunoglobulins.
D. The T4 proteins serve both
to mediate T-cell helper function as well as the receptor for the AIDS
virus.
E. Both of the markers are
present on ALL T-cells.
29. Which of the following is NOT true of the ability
of the T-cell receptor (TCR) to specifically recognize antigen?
A. The antigen must be
"processed" first by an accessory cell of immune system in order for
it to bind to the TCR.
B. The recognition of the
antigen by the TCR can mediate helper, suppressor or cytotoxic function.
C. The recognition of antigen
by the TCR can result in cytokine secretion and/or an increase in cell
proliferation within the immune system.
D. The antigen is recognized by
the T3-TCR complex only when it is associated with a protein of the major
histocompatibility complex
E. Only the alpha chain of the
TCR is necessary for antigen
30. For the
following questions, choose:
A. if only 1,2, and 3 are true
B. if only 1 and 3 are true
C. if only 2 and 4 are true
D. if only 4 is true
E. if all are true
31. Complement fixation
1. can be modified by the Cholera toxin
2. has intrinsic Guanylate cyclase activity
3. can be desensitized by phosphorylation
4. is an effector function of IgG and IgM following antigen binding
32. IgE
is
1. An allergy associated immunoglobulin
2. the least abundant immunoglobulin in the plasma
3. binds to mast cells
4. can cross the placental barrier
33. IgE
1. is produced by mast cells
2. is produced by B-cells
3. is produced by T-cells
4. binds to mast cells
34. Which of the following are true statements
1. IgM and IgG can fix complement
2. IgA is a secretory immunoglobulin
3. IgE mediates immediate hypersensitivity
4. IgD provides most passively acquired maternal immunity
35. IgE is
1. An immunoglobulin associated with some kinds of allergic
reactions
2. the least abundant typo at antibody synthesized
3. associated with tle mast cell for histamine release
4. produced during the primary immune response before class switching
36. Antibodies are
1. Immunoglobulins
2. composed of variable and constant region domains
3. made of heavy and light chains
4. glycoproteins
37. The antigenic determinate
1. is the combining site of an antibody
2. is usually no more than five or six amino acids of the antigen
3. is the paratope
4. Consists of a small topological feature of the antigen
38. A critical property of an antigen is
1. Its ability to stimulate an immune response
2. a unique topotogical feature called an paratope
3. a unique topological feature called an epitope
4. not a unique topological feature called an antigenic determinant
39. An antigenic determinant is
1. a small topological feature of a large macromolecule such as A protein
or carbohydrate
2. specifically recognized by a epitope
3. specifically recognized by a paratope
4. specifically recognized by the T4 protein
40. Immunoglobins
1. are antibodies
2. are classified into five major classes, i.e., IgM, IgG, IgA, IgD,
IgE
3. have a molecular specificity to recognize unique epitope
4. possess both variable and constant region domains
41. The basic monomeric Immunoglobulin unit is
1. composed of four; polypeptide chains
2. only an integral membrane protein and never secreted
3. one of five major classes
4. synthesized by a T-cell without carbohydrate
42. Antibodies
1. are carbohydrates
2. are made from alpha and beta chains
3. contain no carbohydrate
4. contain heavy and light chains
43. The basic monomeric immunoglobulin unit is
1. composed of four polypeptides chains
2. representative of a single protein type for all antibody classes
3. able to associate with J- chain to form multimers in some cases
4. the same structure as the T-cell antigen receptor
44. The basic monomeric form of an immunoglobulin
1. is a tetramer consisting of two light and two heavy chains
2. is associated with J-chain in the IgD
3. can occur as multimers with IgA and IgM
4. exists only on the cell surface of B-cells
45. Class II MHC proteins are
1. Recognized by the T4 (or CD4) protein
2. used to mark a cell for killing by cytotoxic T-cells
3. used to participate in helper function
4. not able to carry an antigen fragment
46. The major histocompatibility complex proteins
function to
1. degrade T4 and T8 polypeptides
2. bind antibody for lymphokine production
3. bind complement for cell lysis
4. bind antigen fragments for presentation to T-cells
47. Class I MHC proteins are
1. able to carry an antigen fragment
2. recognized by the T8 (or CD8) protein
3. used in combination with an antigen fragment to mark a cell for
killing by cytotoxic T-cells
4. used' to participate in helper function
48. Which Is TRUE for BOTH the T-cell antigen receptor
and the antibody
1. They undergo class switching
2. They can be secreted
3. They possess J-chains
4. They can exist as cell surface receptor, integral membrane
proteins.
49. The T-cell antigen receptor and antibody share the
following
features
1. They contain variable and constant region domains
2. They both possess paratopes that can recognize epitopes
3. They are associated with accessory proteins necessary for signal
transduction after antigen recognition
4. They are multivalent
50. Which properties do the T-cell receptor and the
antibody share in common
1. Both recognize antigen or antigen fragments
2. Both are able to fix complement
3. Both are composed of multiple polypeptide chains folded into discrete
domain units
4. Both are composed of four polypeptide chains
51. The antigen combining site of the T-cell receptor
and antibody are
1. located at the amino terminal of the structures
2. a pocket complementary' to the epitope
3. capable of combining with a single antigenic determinant
4. identified by light chain kinase
0 comments:
Post a Comment