Original Article
Population
Based Survey of Glucose-6-Phosphate Dehydrogenase(G6PD) Deficiency among
People Living in Terai Districts of Nepal
Niraj
Lamichhane1, Nabaraj Adhikari2, Upendra Thapa Shrestha 2,
Komal Raj Rijal2, Megha Raj Banjara2, Prakash Ghimire2*
1 Department of Microbiology, Kantipur College of Medical Science,
Sitapaila, Kathmandu
2 Central Department of Microbiology, Tribhuvan University, Kirtipur,
Kathmandu
*Corresponding
Author:
Dr. Prakash Ghimire; Central Department of Microbiology, Tribhuvan University,
Kirtipur, Kathmandu; Email: prakash.ghimire@microbiotu.edu.np
ABSTRACT
Objective:
This
study was carried out to determine the prevalence of Glucose-6-phosphate
dehydrogenase (G6PD) deficiency among population of selected malaria endemic
districts in central and eastern terai of Nepal.
Methods:
Six
hundred seventy whole blood samples were collected from the indigenous
peoples community, identified based on district public health office records
for G6PDd in the past from Jhapa, Morang and Dhanusha districts endemic
to malaria, during April to June 2013. Collected blood samples were tested on
the sites by using BinaxNow G6PD test kit and CareStartTMG6PD test
kits.
Results: The
G6PD deficiency was found to be 6.1% and 6.3% in BinaxNow and CareStartTM
respectively. In 42 G6PD deficient cases, male to female ration was almost
equal. Higher proportions of deficient cases were from Rajbanshi and Santhal
communities, than others. Highest number of deficient cases was in Jhapa
followed by Morang and Dhanusha districts respectively.
Conclusion: G6PD
deficiency in indigenous population groups in eastern and central terai are
heterogenous, so testing of G6PD before initiation of radical treatment for P
vivax infection would be important for reducing the risk of hemolysis following
PQ administration, and rational evidence based PQ administration may be helpful
in contributing towards elimination of malaria from the country.
For full article: Please download from the link below
https://microbiotu.edu.np/index.php/journals/
For Citation: Lamichhane et al., 2017 TUJM Vol 4(1): 73-78
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