Friday, August 18, 2023

BMC Pediatrics



Burden of Human Metapneumovirus infections among children with acute respiratory tract infections attending a Tertiary Care Hospital, Kathmandu

Jyoti Lamichhane1 #, Milan Upreti1 #, Krishus Nepal1, Bishnu Prasad Upadhyay2, Urusha Maharjan2, Ram Krishna Shrestha2, Ram Hari Chapagain3, Megha Raj Banjara4, Upendra Thapa Shrestha4*

 

1GoldenGate International College, Battisputali, Kathmandu, Nepal

2Central Diagnostic Laboratory & Research Center, Kamalpokhari, Kathmandu, Nepal

3Kanti Children’s Hospital, Maharajgunj, Kathmandu, Nepal

4Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal

 

# The authors have equal contributions to the study.

 

* Corresponding Author: Upendra Thapa Shrestha, Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal. Email: upendrats@gmail.com

 

 

ABSTRACT

 

Background Acute respiratory infections (ARIs) are one of the most common causes of mortality and morbidity worldwide.  Every year millions of children suffer from viral respiratory tract infections (RTIs) ranging from mild to severe illnesses. Human Metapneumovirus (HMPV) is among the most frequent viruses responsible for RTIs. However, HMPV infections and their severity among children have not been explored yet in Nepal. Purpose Therefore, the study was focused on HMPV infections and with other potential viral etiologies or co-infections using multiplex PCR among children attending Kanti Children’s Hospital and assess the clinical characteristics of the infections as well as find out the co-infections. A hospital based cross-sectional study was designed and a convenience sampling method was used to enroll children of less than 15 years with flu like sumptoms from both outpatients and inpatients departments over three month of the study period.

Results HMPV infection (13.3%) was the most predominant infection among the different viral infections in children with ARIs in Kanti Children’s Hospital. The HMPV was more prevalent in the age group less than three years (21.8%). Cough and fever were the most common clinical features present in all children infected with HMPV followed by rhinorrhea, sore throat, and wheezing.  HMPV-positive children were diagnosed with pneumonia (42.9%), bronchiolitis (28.5%), upper respiratory tract infections (14.3%), and asthma (14.3%). The prevalence of HMPV was high in late winter (14.3%) followed by early spring (13.5%).

Conclusions This study provides the baseline information on HMPV and associated co-infection with other respiratory viruses for the differential diagnosis based on molecular methods and also the comparison of clinical presentations among the different respiratory syndromes.

Keywords Respiratory tract infections, Human Metapneumovirus, Multiplex real-time RT-PCR, Pneumonia, Bronchiolitis


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